Recruitment

Organovir is a Marie Skłodowska-Curie Action (MSCA) training network with a consortium consisting of excellent universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, Poland, Denmark, the United Kingdom and the United States of America.

 

Organovir will provide 15 Early Stage Researchers (ESRs) with the unique opportunity to be trained within a consortium that will enable them to lead innovation in the field of organoids for virus research.

 

We are currently looking for highly motivated and talented ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see all vacancies and their specific requirements below).

 

The deadline for applications is the 1st of April, 2019.

Questions about a vacancy? Feel free to contact us and we'll get back to you as soon as possible!

Organovir is looking for candidates who

  • Have a Master degree in the field of virology, biochemistry, cell biology, molecular biology, tissue engineering, life sciences/medicine, social sciences, pharmaceutical sciences, law, communications, economics, science ethics or business, or will obtain a Master degree by September 2019
  • Are willing to undertake trans-national mobility (e.g. move from one country to another) to perform research abroad
  • Are highly motivated and talented
  • Are proficient in the English language
  • Have excellent communication skills
  • Have obtained high grades during her/his studies
  • Interest and experience in virus culture and organoid technology is an advantage
  • Fulfil the eligibility criteria for a Marie Skłodowska-Curie Action (MSCA) training network H2020 (see the eligibility criteria below)

Organovir offers

  • Highly competitive and attractive salary and working conditions
  • Challenging research projects to lead to a dissertation (PhD thesis)
  • The opportunity to become an expert in the field of organoids for virology & hold a unique position within the European labour market
  • Training in state-of-the-art scientific skills and transferable managerial skills
  • Training in academic and industrial settings
  • Intersectoral secondments to gain work experience in different environments
  • The opportunity to become highly employable in both academic and non-academic sectors
  • The obtainment of a pre-MBA certificate
  • Excellent facilities for research

Eligibility criteria

You are eligible to apply for an ESR position if you meet the following conditions:

 

Early-stage researchers (ESR) are those who are, at the time of recruitment by the host institution, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged.

 

Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host institution, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.

Interested in joining Organovir and do you meet all the requirements as well as the eligibility criteria?

Vacancies

ESR 1: Coronavirus with HAE model

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April 2019.

 

 

 

Project title: Complex HAE model for studies on coronavirus pathogenesis (ESR 1)

 

Host institution: Jagiellonian University, Poland. The research will be carried out in a young and dynamic team lead by Krzysztof Pyrc. The Jagiellonian University is located in the historical, yet vibrant city of Krakow.

 

 

About the host institution

 

The team of prof. Krzysztof Pyrc works at two faculties: Faculty of Biochemistry, Biophysics and Biotechnology (FBBB) and Malopolska Center of Biotechnology (MCB). The first unit is teaching/training-oriented, the second unit (with high-containment laboratories) functions as a R&D unit, with state of the art facilities. FBBB JU is the best biology/biotechnology faculty in Poland, according to the 2017 governmental scientific unit assessment. The MCB is the first University – based research institute and at the same time the excellence center. It gathers excellent internationally renowned scientists and laboratories (including Max Planck laboratory and CNRS), and periodic evaluation of researcher coordinated by the independent, international advisory board ensures high scientific quality.

 

The focus of the research group is on the understanding of the infection process of human viruses and the interplay between the virus and the host cell, and translation of these results to the applicatory field. They have recently developed several virus inhibitors, some are in the stage of (pre-) commercialization (HTCC compound for animal coronaviruses, NSPAH polymer as broad antiviral compound, www.virogenetics.info). The teams’ expertise with human 3D cell culture models encompasses mainly human airway epithelium (HAE) cultures formed by primary human epithelial cells on an air/liquid interphase. They have successfully cultured type I and type II pneumocytes. Clinical material preparation (human lungs), cell isolation and differentiation are carried out in house. Further, the methods allowing for modification of 3D cultures (lentiviral gene engineering, gene silencing, co-cultures) and analysis (confocal microscopy, 3D virtualization, SEM, superresolution microscopy) allow to study viral infection in the context of natural tissue.

 

 

Project description

 

This project focuses on novel 3D complex model system to study infection with respiratory viruses. During this project, you will be focussing on the following research objectives:

 

  • To create a model for human airway epithelium allowing to study the interplay between the virus and our immune system.
  • To test what happens during coronaviral infection in such a model.
  • To understand what happen on a single cell level. Big data.

 

 

With this project, we aim to achieve the following results:

 

  • Develop complex HAE tissue, combining different cell types to reflect the interaction between the pathogen and the immune system.
  • On tissue level: map coronaviral infection, cell-to-cell spread, potential of immune cells as carriers, pathogenesis.
  • On single cell level: analyse the microenvironment of the cell, innate immunity, virus-cell interaction, virus specificity.

 

This project also includes two secondments, which are as follows:

 

  • A two-month secondment with Danmarks Tekniske Universitet (location: Lyngby, Denmark) focused on novel biomaterials / solutions for advanced 3D cultures.
  • A three-month secondment with the Universiteit van Amsterdam (location: Amsterdam, the Netherlands) focused on bringing gut organoids to JU and bringing complex HAE cultures to UvA.

 

The research will be carried out in a young and dynamic team lead by Krzysztof Pyrc (Virogenetics Laboratory of Virology), who will guide you during the research project.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, life sciences and related. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 40 hours per week within a motivated and innovative consortium. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 2: Hydrogels, HAE gut

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

 

 

Project title: Hydrogels, a co-culture system linking gut to endothelium (ESR 2)

 

Host institution: Department of Healthcare technology, Technical University of Denmark, Denmark

 

 

About the host institution

 

The DTU Health Technology Department located at the so-called “Medicon Valley”, is an international-class research platform where around 300 researchers work together to provide new technology and new solutions to improve the quality of patient care and public health and well-being.

 

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.

 

 

Project description

 

In this specific project, we focus on making scalable hydrogel system for high throughput screening and increased cell or organoid functionalities. During this project, you will be focussing on the following research objectives:

 

  • To construct a stackable co-culture systems with flexible hydrogels
  • To scale the stackable system into 96-well plate format
  • To place organoids behind epithelial layer and/or endothelial layer to simulate coupled organ system
  • Model virus propagation in the system
  • Provide chemical and 3D cues to improve organoid function and organisation.

 

 

Responsibilities and tasks

 

The candidate will be responsible for the development of the system and testing the systems for compatibility with organoid cultures. The candidate is expected to be open to collaborations and actively participate in the training network. Specifically, this includes collaborating with other PhD students in the program and in at the departments and to carry out two secondments:

 

  • A three-month secondment Academisch Medisch Centrum bij de Universiteit van Amsterdam (location: Amsterdam, the Netherlands) focused on transfer of stackable hydrogel technology
  • A three-month secondment with the University of Jagiellonski (location: Krakow, Poland) focused on learning about cocultures of fibroblasts and immune cells.

You will be guided during your research project by Martin Dufva, Department of Healthcare engineering, Technical University of Denmark.

 

 

Requirements

 

Candidates should have a two-year master’s degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master’s degree.

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field tissue engineering or similar. Interest and experience in 3D printing, microfluidics, and working with mammalian cell cultures is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. Due to the grant mobility aspects, the applicant must not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.

 

 

Approval and Enrolment

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.

 

 

Assessment

The assessment committee will consist of members of the Organovir research leader team.

 

 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

 

 

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

 

You can read more about career paths at DTU here.

 

 

Further information

Further information may be obtained from Martin Dufva, tel.: +45 51 33 37 53.

 

You can read more about “the Department of Health Technology” at www.healthtech.dtu

 

 

Application

Please apply via the application form on the Organovir website AND submit your online application at www.career.dtu.dk .The deadline for applications is the 1st of April, 2019.

 

To apply via the DTU website, please open the link “Apply online”, fill out the online application form. The following must be attached in English:

 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)

 

Candidates may apply prior to ob­tai­ning their master’s degree but cannot begin before having received it.

 

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

ESR 3: Enterovirus, blood brain barrier

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April 2019.

 

 

 

Project title: 3D model of the human blood-brain barrier (BBB) to study enterovirus (EV) pathogenesis (ESR 3)

 

Host institution: University Clermont Auvergne (France) – Research Unit LMGE CNRS 6023 – EPIE team “Epidemiology and pathogeny of enterovirus infections”.

 

 

About the host institution

 

Université Clermont Auvergne (UCA) is a multidisciplinary higher education institution located in Clermont-Ferrand, a city located in the middle of France. With 35,000 students, including 4,600 (13%) international ones, and 3,300 staff, UCA plays a key role in the territorial structuration and the building of a European level region. Its 20 Faculties and 5 Doctoral Schools offer more than 170 training programs.

 

It also hosts 39 research units and laboratories and is committed in several laboratory of excellence, regional clusters and competitiveness centres. The UCA and its regional partners are one of the 12 major research centres in France to have been awarded the I-Site label (in 2017) (Initiatives – Science – Innovation – Territories – Economy), which puts the Clermont-Ferrand university site on the map of excellence in higher education and research at national and international level.

 

UCA is participating to Organovir on behalf of the LMGE joint research unit between UCA and the ‘Centre National de la Recherche Scientifique’ (CNRS). Among the 6 teams of LMGE, the EPIE team takes part in the Organovir project.

 

The EPIE team works in close relationships with the department of medical virology and the National Reference Center (NRC) of enteroviruses and parechoviruses at the University hospital of Clermont-Ferrand. The activities of the NRC comprise the epidemiological and clinical surveillance of enterovirus infections.

 

 

Project description

 

The objectives of this project are:

 

  • Develop a 3D physiologically relevant model of the BBB that mirrors cell organization of the brain
  • Investigate the benefit of including minibrains in the development
  • Standardisation of minibrain infection with EVs
  • Investigate the mechanism (axonal transport or passage through BBB) for brain infection of EVs

 

During this project, we aim to achieve the following results:

 

  • Development of a novel 3D model of the human BBB with co-culture of neurons, astrocytes, and endothelial cells
  • Elucidation of molecular and cellular mechanism that underlie pathogenic processes of different neurotropic EVs

 

This project also includes a four-month secondment at the Technical University of Denmark (location: Lyngby Campus, Martin Dufva’s Lab). The secondment will focus on learning how to use advanced compartmentalized microfluidic platforms.

 

During your research project, you will be guided by Jean-Luc Bailly (LMGE CNRS 6023, EPIE team).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of cell biology, virology, tissue engineering, life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 3-year research position for 37.5 hours per week within a motivated and innovative consortium. The salary is in accordance with ITN rules, and includes (charges amounts):

 

a living allowance: 3783.39 € per month

a mobility allowance: 600 € per month

– and, if the candidate has a family at the date of recruitment ((i) marriage, or (ii) a relationship with equivalent status to a marriage recognised by the national or relevant regional legislation of the country where this relationship was formalised; or (iii) dependent children who are actually being maintained by the researcher), a family allowance: 500€ per month.

 

The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 4: Skin model, enterovirus

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Co-culture model of human keratinocytes with dermal microvascular endothelial cells (ESR 4)

 

Host institution: University of Clermont Auvergne (France) – Research Unit EPIE “Epidemiology and pathogeny of enterovirus infections” (LMGE CNRS 6023)

 

 

About the host institution

 

Université Clermont Auvergne (UCA) is a multidisciplinary higher education institution located in Clermont-Ferrand, a city located in the middle of France. With 35,000 students, including 4,600 (13%) international ones, and 3,300 staff, UCA plays a key role in the territorial structuration and the building of a European level region. Its 20 Faculties and 5 Doctoral Schools offer more than 170 training programs.

 

It also hosts 39 research units and laboratories and is committed in several laboratory of excellence, regional clusters and competitiveness centres. The UCA and its regional partners are one of the 12 major research centres in France to have been awarded the I-Site label (in 2017) (Initiatives – Science – Innovation – Territories – Economy), which puts the Clermont-Ferrand university site on the map of excellence in higher education and research at national and international level.

 

UCA is participating to Organovir on behalf of the LMGE joint research unit between UCA and the ‘Centre National de la Recherche Scientifique’ (CNRS). Among the 6 teams of LMGE, the EPIE team takes part in the Organovir project.

 

The EPIE team works in close relationships with the department of medical virology and the National Reference Center (NRC) of enteroviruses and parechoviruses at the University hospital of Clermont-Ferrand. The activities of the NRC comprise the epidemiological and clinical surveillance of enterovirus infections.

 

 

Project description

 

This project aimed at developing a skin-like model to study the pathogenesis of hand, foot and mouth disease (HFMD) which can be caused by several types of enteroviruses. Hand, foot and mouth disease is a very common childhood disease characterised by vesicular eruption of the soles and the palms and by oral ulcerations. It is usually a benign illness but some children can develop more severe symptoms (body-wide skin rashes, large skin blisters …). A national sentinel surveillance network composed of primary care pediatricians is currently in place in France.

 

During this project, you will be focusing on the following research objectives:

 

  • Develop a culture model system for human keratinocytes (human epidermis like culture)
  • Grow the epidermis-like culture on a basal layer including dermal fibroblast and dermal microvascular endothelial cells)
  • Compare different EV types for their ability to infect the cell types in the skin-like tissue.

 

With this project, we aim to achieve the following results:

 

  • Establishment of a skin-like model to study pathogenesis of HFMD
  • Elucidation of host immune effectors or viral genetic factors involved in the dermotropism of enteroviruses

 

This project also includes two secondments, which are as follows:

 

  • A three-month secondment at the National Institute for Public Health and the Environment (location: Amsterdam, the Netherlands) focused on clinical network formation for HFMD outbreaks.
  • A three-month secondment at the Technical University of Denmark (location: Lyngby, Denmark) focused on linking epidermis to connective tissue harbouring dermal fibroblasts and microvascular endothelial cells.

 

You will be guided during your research project by Dr. Audrey Mirand (LMGE CNRS 6023, EPIE team and Department of Medical Virology).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field cell biology, molecular biology, virology, tissue engineering, life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 3-year research position for 37.5 hours per week within a motivated and innovative consortium. The salary is in accordance with ITN rules, and includes (charges amounts):

 

a living allowance: 3783.39 € per month

a mobility allowance: 600 € per month

– and, if the candidate has a family at the date of recruitment ((i) marriage, or (ii) a relationship with equivalent status to a marriage recognised by the national or relevant regional legislation of the country where this relationship was formalised; or (iii) dependent children who are actually being maintained by the researcher), a family allowance: 500€ per month.

 

The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 5: Medium, HAE

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April 2019.

 

 

 

Project title: Develop and validate specific medium for human lung organoid culture (ESR 5)

 

Host institution: STEMCELL Technologies UK Ltd. Cambridge, UK

 

 

About the host institution

 

STEMCELL Technologies Inc. is a privately-owned biotechnology company based in Vancouver that helps power leading-edge life science research around the world. Scientists performing stem cell, immunology, cancer, regenerative medicine and cellular therapy research are among those who rely on our cell culture media, cell separation products, instruments, ancillary reagents and contract assay services. We create novel, useful, standardized products of unfailing quality and deliver them to more than 70 countries via our many regional offices plus distribution centres in Vancouver, Seattle, Grenoble and Singapore.  Driven by our love of science and our passion for quality, we see ourselves simply as “Scientists Helping Scientists” – standing by our customers to provide outstanding products, technical support and training.  We have over 1000 science-oriented employees globally, including 250 PhDs/MScs, with most others holding a BSc or engineering degree.  STEMCELL is proud to be the largest Biotechnology employer in Canada.

 

STEMCELL is continuing to expand its European operations, particularly in the areas of R&D personnel and facilities, manufacturing, quality control, quality assurance and regulatory activities that will meet the highest levels of European research and regular standards. STEMCELL UK Ltd. (STUK) was established in July 2014. In 2016 STUK expanded its capabilities to include research and development (R&D) with staff located in laboratory space in Cambridge, UK, including fully functional laboratory space containing state of the art cell culture and analytical chemistry equipment as well as an ISO 13485-certified manufacturing clean room that is adopting single use technology and closed systems for manufacturing higher compliance media and culture reagents.

 

 

Project description

 

This project focuses on lung organoid culture and its application to respiratory virus study. During this project, you will be focusing on the following research objectives:

 

  1. Develop medium for human distal lung organoid culture
  2. Functional validation of the distal lung organoids (e.g., characterization of effects of virus infection on these lung organoids
  3. Upscaling the production of lung organoid medium

 

This project also includes one six-month secondment with Department of Medical Microbiology, Amsterdam University Medical Canters (Amsterdam UMC) focusing on virus study.

 

You will be guided during your research project by Juan Hou (Pulmonary research specialist at STEMCELL Technologies Vancouver) and Wing Chang (Pluripotent Stem cell specialist at STEMCELL Technologies UK).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology or stem cell biology. Interest and experience in hPSC culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 36 hours per week within a motivated and innovative consortium. The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 6: Influenza A virus, mucosa

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Virus-host interactions at the mucosal interface (ESR 6)

 

Host institution: Virology Division, Department of Infectious Diseases & Immunology, Utrecht University, the Netherlands

 

 

About the host institution

 

The Utrecht University (UU) is the top Dutch university (Shanghai Ranking), while its Faculty of Veterinary Medicine (FVM) belongs to the top 5 veterinary research institutes in the world. The UU offers 45 undergraduate and 167 graduate programs, has some 30,000 students served by 7,500 academic staff, and has 6 graduate schools. The ESR will be enrolled in the Graduate School of Life Sciences. The Virology division of the Faculty of Veterinary Medicine studies various viruses (picornavirus, coronavirus, influenza) at the level of molecules, cells, tissues, and organisms, to unravel the structure of these viruses and to identify their cellular receptors, entry pathways, replication mechanisms, assembly and release pathways, immune evasion strategies, as well as the mechanism of disease caused by these viruses (i.e. pathogenesis). Furthermore, based on our intensive studies in glycans (e.g. sialic acids) as virus receptor, we have established strong scientific and technological expertise in the field of “glycovirology”. Our ultimate goal is to translate the knowledge that we obtain into the development of novel vaccines, antiviral therapies, and diagnostic tools. The Virology Division is headed by Prof. Frank van Kuppeveld.

 

 

Project description

 

This project is aimed at better understanding the interaction of respiratory viruses with their glycan receptors and how they navigate through the heavily sialylated mucus barrier overlaying the epithelial cells of the respiratory tract, focussing on influenza A viruses and enterovirus-D68 (EV-D68).

 

Influenza A viruses infect birds and mammals such as swine and humans. They have sialic acid receptor-binding hemagglutinin (HA) and receptor-cleavage neuraminidase (NA) proteins. The functional balance between these proteins is thought to be important for host tropism and pathogenesis. This balance is , however, poorly characterized and molecular details are largely lacking. In this project, we will focus on the HA-NA balance of human and swine influenza A viruses and the importance thereof for host tropism, with particular focus on the interaction of these viruses with the heavily sialylated mucus barrier overlaying the epithelial cells of the respiratory tract. The HA-NA balance of human and swine viruses will be studied for different functional and decoy receptors including mucus by using innovative biolayer interferometry assays (Guo et al., PLoS Pathog. 2018. 14(8):e1007233).

 

EV-D68 is an emerging respiratory virus that is also associated with paralysis. It also relies on sialic acid to infect cells, but this non-enveloped virus lacks a receptor-destroying enzyme. Whether mucus enhances or inhibits infection of epithelial cells is unknown. The role of sialic acid  receptors as well as protein receptors for infection will be studied as well as the identity of the cell types that are infected with different EV-D68 strains.

 

For this project, we will establish airway epithelial cell cultures, of human and swine origin, which will be used for infection studies and for harvesting of mucus. Mucus samples will also be characterized in detail for their protein and glycan content and for their ability to inhibit virus infection.

 

This project also includes two secondments, which are as follows:

 

  • A two-month secondment with Epithelix Sarl (location: Genève, Switserland) to learn more about setting up human airway epithelial cell cultures and collection of mucus.
  • A two-month secondment with the University of Genève (location: Genève, Switserland) focused on the handling of these cultures for infection studies.

 

You will be guided during your research project by Dr. C.A.M. (Xander) de Haan and Prof. F.J.M. (Frank) van Kuppeveld (both from the Virology Division of the Utrecht University).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, and/or virology. Interest and experience in molecular virology and air-liquid interface cultures of epithelial cells is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 36 hours per week within a motivated and innovative consortium. The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 7: Coronavirus & cross-species infectivity

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Coronaviruses: cross–tissue and cross–species infectivity (ESR 7)

 

Host institution: Jagiellonian University, Poland. The research will be carried out in a young and dynamic team lead by Krzysztof Pyrc. The Jagiellonian University is located in the historical, yet vibrant city of Krakow.

 

 

About the host institution

 

The team of prof. Krzysztof Pyrc works at two faculties: Faculty of Biochemistry, Biophysics and Biotechnology (FBBB) and Malopolska Center of Biotechnology (MCB). The first unit is teaching/training-oriented, the second unit (with high-containment laboratories) functions as a R&D unit, with state of the art facilities. FBBB JU is the best biology/biotechnology faculty in Poland, according to the 2017 governmental scientific unit assessment. The MCB is the first University – based research institute and at the same time the excellence center. It gathers excellent internationally renowned scientists and laboratories (including Max Planck laboratory and CNRS), and periodic evaluation of researcher coordinated by the independent, international advisory board ensures high scientific quality.

 

The focus of the research group is on the understanding of the infection process of human viruses and the interplay between the virus and the host cell, and translation of these results to the applicatory field. They have recently developed several virus inhibitors, some are in the stage of (pre-) commercialization (HTCC compound for animal coronaviruses, NSPAH polymer as broad antiviral compound, www.virogenetics.info). The teams’ expertise with human 3D cell culture models encompasses mainly human airway epithelium (HAE) cultures formed by primary human epithelial cells on an air/liquid interphase. They have successfully cultured type I and type II pneumocytes. Clinical material preparation (human lungs), cell isolation and differentiation are carried out in house. Further, the methods allowing for modification of 3D cultures (lentiviral gene engineering, gene silencing, co-cultures) and analysis (confocal microscopy, 3D virtualization, SEM, superresolution microscopy) allow to study viral infection in the context of natural tissue.

 

 

Project description

 

This project focuses on the potential of coronaviruses to cross tissue and species borders using 3D ex vivo cultures. During this project, you will be focussing on the following research objectives:

 

  • To create a model for coronaviral infection of the human gut, human and animal HAE cultures.
  • To test infection of different tissues with human and animal coronaviruses.
  • To understand determinants of the infection: receptor usage, cellular proteases, internalization pathways, other factors restricting viral replication.

 

With this project, we aim to achieve the following results:

 

  • Develop human and animal 3D gut and airway models to complement the existing ones.
  • On tissue level: identify factors limiting cross-tissue and cross-species transfer.
  • On single cell level: to understand what the virus needs to start the infection and to produce viable progeny.

 

This project also includes three secondments, which are as follows:

 

  • A three-month secondment with the Universiteit van Amsterdam (location: Amsterdam, the Netherlands) focused on bringing gut organoids to JU.
  • A six-month secondment with Universiteit Utrecht (location: Utrecht, the Netherlands) focused on viral infections of different tissues / species.
  • A one-month secondment with Stemcell Technologies UK LTD (location: Cambridge, United Kingdom) focused on commercial aspects of the research.

 

The research will be carried out in a young and dynamic team lead by Krzysztof Pyrc (Virogenetics Laboratory of Virology), who will guide you during the research project.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, life sciences and related. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 40 hours per week within a motivated and innovative consortium. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 8: Respiratory microbiota & respiratory viruses

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Effect of commensal bacteria on viral respiratory infections (ESR 8)

 

Host institution: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Switzerland

 

 

About the host institution

 

The Faculty of medicine of the University of Geneva Medical School (an important research institution in Switzerland) leads internationally recognized research, in partnership with the largest hospital complex in Switzerland, the Geneva University Hospitals (HUG). Over 250 research groups are divided into three main sections (fundamental, clinical and dental medicine) showing a major translational research capacity. The Department of Microbiology and Molecular Medicin (MIMOL), one of the six departments leading fundamental research, studies the biology of microorganisms (parasites, fungi, bacteria and viruses), and their interactions with the infected host. The Biology-Medicine PhD school supervises and educates students who undertake a PhD thesis in life sciences within the Faculty of Medicine.

 

 

Project description

 

This project focuses on viral and bacterial interactions in the respiratory tract, more specifically, on how commensal bacteria present in the airways impact on the virulence of respiratory viruses.

 

During this project, you will be focussing on the following research objectives:

 

  • Assess the effect of commensal bacteria on the replication of respiratory viruses both in vitro and ex vivo in respiratory tissues.
  • Investigate the mechanism of action underlying the dynamics between commensal bacteria and viral pathogens.

 

With this project, we aim to better understand the nature and the mechanism of viral-bacterial interactions in the respiratory tract. This knowledge will help to improve patient management and drug/vaccine design.

 

The project includes two secondments in the Epithelix Company [http://www.epithelix.com/] in order to learn how to reconstitute respiratory epithelia from patient biopsies and in order to set up co-cultures of airway tissues and macrophages or dendritic cells.

 

The PhD student will be guided during his PhD by Prof. Caroline Tapparel Vu and Dr.Chiara Medaglia.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent master degree. Experience in the field of virology, bacteriology, cell biology, molecular biology or tissue engineering is an advantage. The candidate is required to be proficient in the English language. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out his/her work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position within a motivated and innovative consortium. The salary is in accordance with Swiss National Science Foundation standards.  The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 9: Parecho-3 virus in gut models

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: PEV3 infection: determinants of susceptibility (ESR 9)

 

Host institution: Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), the Netherlands

 

 

About the host institution

 

Amsterdam University Medical Centers (Amsterdam UMC) is one of the foremost research institutions in the Netherlands and one of its largest hospitals, with 1500 staff members employed in medical research. The Amsterdam UMC research is organized in 7 themes within the AMC Research Institute, where AMC Principal Investigators (PIs) are appointed to develop their own research lines. The AMC Graduate School organizes doctorate level academic training of AMC PhD students (209 PhD rewarded in 2016). This concentration of expertise makes the center a breeding ground for fruitful scientific collaborations.

 

 

Project description

 

This project focuses on researching the determinants of susceptibility regarding the PEV3 infection. During this project, you will be focussing on the following research objectives:

 

  • Identify the role of viral genotype and donor age in determining susceptibility of human gut to infection with PEV3
  • Identify which cells are infected by PEV3 in human gut & respiratory tissue
  • Establish the known role of PEV3 receptors in infecting human gut & respiratory tissues

 

With this project, we aim to achieve the following results:

 

  • Establishment of the HAE PEV3 infection
  • Establishment of human infection models to study pathogenesis of PEV3
  • Identification of viral factors (mutations) and host factors (age, tissue, receptor expression) that affect susceptibility of host cells to infection with PEV3

 

This project also includes two secondments, which are as follows:

 

  • A two-month secondment with Charles River (location: Leiden, the Netherlands) focused on bringing gut organoids from the Amsterdam UMC to Charles River.
  • A three-month secondment with the University of Jagielloński (location: Krakow, Poland) focused on learning about advanced cell staining and receptor identification.

 

You will be guided during your research project by Katja Wolthers (Department of Medical Microbiology) and Dasja Pajkrt (Paediatric Infectious Disease Specialist).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, pharmaceutical sciences or life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 36 hours per week within a motivated and innovative consortium. The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 10: New EVs on organoids

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Propagation of uncultivable EV/HPeV infection in human 3D models (ESR 10)

 

Host institution: Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), the Netherlands

 

 

About the host institution

 

Amsterdam University Medical Centers (Amsterdam UMC) is one of the foremost research institutions in the Netherlands and one of its largest hospitals, with 1500 staff members employed in medical research. The Amsterdam UMC research is organized in 7 themes within the AMC Research Institute, where AMC Principal Investigators (PIs) are appointed to develop their own research lines. The AMC Graduate School organizes doctorate level academic training of AMC PhD students (209 PhD rewarded in 2016). This concentration of expertise makes the center a breeding ground for fruitful scientific collaborations.

 

 

Project description

 

This project focuses on researching the propagation of uncultivable EV/HPeV infection in human 3D models. During this project, you will be focussing on the following research objectives:

 

  • To culture EV-C types 104, 105, 109 and 116-118 positive samples on 3D models
  • To culture HPeV8-16 positive samples on 3D models
  • To study virus replication kinetics, viral entry, and effects on gut, lung/HAE or brain organoids

 

With this project, we aim to achieve the following results:

 

  • The successful propagation of one or more EV/HPeV for further characterization of viral replication, tropism and virus-host interaction.

 

This project also includes two secondments, which are as follows:

 

  • A seven-month secondment with The National Institute for Public Health and the Environment (RIVM) focused on bringing HAE to the RIVM and to collect samples for cultivation (location: Bilthoven, the Netherlands)
  • A three-month secondment with the University of Clermont Auvergne focused on learning about the mini-brain model (location: Clermont-Ferrand, France)

 

You will be guided during your research project by Katja Wolthers (Department of Medical Microbiology) and Dasja Pajkrt (Paediatric Infectious Disease Specialist).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering or life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 4-year research position for 36 hours per week within a motivated and innovative consortium. The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 11: HAE, respiratory viruses, antiviral testing

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Optimize viral replication in primary human airway epithelial (HAE) cells for use in antiviral research to combat respiratory viral infections (ESR 11)

 

Host institution: Department of Microbiology and Immunology, Rega Institute, KULeuven, Leuven, Belgium.

 

 

About the host institution

 

In 2016 and 2017 the University of Leuven (KUL) was listed by Thomson Reuters in the annual list of Europe’s most innovative universities. The Rega Institute for Medical Research (KUL-REGA) is part of the University of Leuven (KUL). It consists of departments of medicine and pharmacology and is a renowned center in Europe contributing to the discovery of novel antiviral and antibacterial treatments (Brivudine, Tenofovir).

 

 

Project description

 

This project focuses on exploring the use of HAE cultures to study the treatment of viral respiratory infections. HAE cultures will be used to evaluate novel antiviral strategies to combat Respiratory Syncytial Virus (RSV) infection and explore the kinetics of replication of different RSV virus strains. This will result in an optimized culture system to be used to characterize viral strains in a relevant ex vivo system and link viral factors with pathogenesis. Using HAE derived from healthy volunteers and COPD patients (provided by P12(ES), the role of RSV in exacerbations of COPD will be studied. Novel antiviral strategies will be evaluated in the RSV/HAE infection model. This will generate important information on the therapeutic potential of the different antiviral strategies, the risk of resistance development and the use of combination strategies. These results will be compared with results from existing animal studies with the aim to reduce the use of these animal models in the future. The role of inflammation in RSV pathology and the effect of antiviral strategies to recover the inflammation will be explored in collaboration with B3(JU). A co-culture of HAE with immune cells obtained from healthy donors will be implemented and infected with several RSV strains. The cytokine profile of the co-cultures will be determined.

 

During this project, you will be focussing on the following research objectives:

 

  • Optimize HAE culture system to study Respiratory Syncytial Virus (RSV) infections.
  • Proof-of-principle that the RSV/HAE can be used to characterize the potency of novel antiviral strategies including the characterization of resistance associated mutations.
  • Proof-of-principle that the co-culture of immune cells and HAE can be used to characterize the potency of novel antiviral strategies against RSV. This would mainly focus on the role of alveolar macrophages in pathology and replication of RSV.
  • Demonstrate that the HAE system can bring important contributions to the drug discovery/development pipeline for respiratory pathogens.

 

This project also includes two secondments, which are as follows:

 

  • A two-month secondment with Epithelix (location: Geneva, Switzerland) focused on learning how to work with HAE cell cultures.
  • A three-month secondment with the University of Jagiellonski (location: Krakow, Poland) focused on learning about co-culture of HAE and immune cells.

 

You will be guided during your research project by Prof. Johan Neyts and Dr. Dirk Jochmans.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering or life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

The selected candidates will be enrolled in a KU Leuven PhD on a full-time basis for 36 months, and will receive a competitive salary in accordance with the EC MSCA regulations for early stage researchers.  Efforts will be made to secure additional funding for the 4th PhD year.

 

In addition to their individual scientific projects, the selected researchers will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 12: Gut, noro- and rotavirus, antiviral testing

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Exploring novel antiviral strategies to combat noro- and rotavirus infections by using gut organoids. (ESR 12)

 

Host institution: Department of Microbiology and Immunology, Rega Institute, KULeuven, Leuven, Belgium

 

 

About the host institution

 

In 2016 and 2017 the University of Leuven (KUL) was listed by Thomson Reuters in the annual list of Europe’s most innovative universities. The Rega Institute for Medical Research (KUL-REGA) is part of the University of Leuven (KUL). It consists of departments of medicine and pharmacology and is a renowned center in Europe contributing to the discovery of novel antiviral and antibacterial treatments (Brivudine, Tenofovir).

 

 

Project description

 

The ESR will investigate viral replication assays in gut organoids towards their use in exploring novel antiviral strategies to combat noro- and rotavirus infections. The major limitation to develop novel small molecule inhibitors for human noro- (HuNoV) and rotaviruses (HRV) is the lack of a robust in vitro or in vivo culture model. Gut organoids will be implemented to study infection and replication of multiple HuNoV and HRV strains. The effect of (i) previously described antivirals with in vitro and/ or in vivo activity; (ii) novel inhibitors identified in a high throughput screening campaign (surrogate virus) of 150 000 molecules; (iii) other biologicals will be studied using this virus/gut organoid system. This will provide a unique opportunity to understand the interactions between these enteric pathogens and the gut epithelia and get further insight into details of their replication, such as viral entry and pathogenesis. Moreover, it will constitute a unique platform to assess the efficacy of inhibitors currently under development against previously uncultivable strains.

 

During this project, you will be focussing on the following research objectives:

 

  • Operational gut organoids for HuNoV- and RV replication and proof-of-principle that these virus- gut organoid infection models can be used to evaluate antiviral strategies including the characterization of resistance associated mutations.
  • Optimize miniaturized organoid cultures that can be used successful for medium-throughput drug screening of gastro-intestinal (GI) viruses.
  • Demonstrate that the gut organoid system can bring important contributions to the drug discovery/development pipeline for GI viruses.

 

This project also includes three secondments, which are as follows:

 

  • A two-week secondment with Hubrecht Institute (location: Utrecht, The Netherlands) focused on learning the basics of gut organoid cultures.
  • A three-month secondment with Charles River (location: Leiden, The Netherlands) to learn how to set up organoids in high throughput.
  • A one-month secondment with STEMCELL Technologies (location: Cambridge, UK) to learn about commercialization processes

 

You will be guided during your research project by Prof. Johan Neyts and Dr. Joana Rocha-Pereira.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering or life sciences. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

The selected candidates will be enrolled in a KU Leuven PhD on a full-time basis for 36 months, and will receive a competitive salary in accordance with the EC MSCA regulations for early stage researchers.  Efforts will be made to secure additional funding for the 4th PhD year.

 

In addition to their individual scientific projects, the selected researchers will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 13: Standardizing organoid cultures, high through put

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Standardizing organoid cultures for high-throughput screening (ESR 13)

 

Host institution: Charles River, Leiden, The Netherlands.

 

 

About the host institution

 

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, to support clients from target identification through preclinical development. Utilizing our broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

 

 

Project description

 

This project focuses on the application of human organoid technology in industrial drug discovery. The purpose of this project is to develop human organoid-based infectious disease models and to apply these in drug screening using a variety of technologies (e.g. (stem) cell culture, high throughput screening, virology/infectious disease, and high content imaging).

 

During this project, you will be focussing on the following research objectives:

 

  • Develop a high throughput system with a human 3D cell infectious disease in vitro model, including relevant readouts
  • Screen a small molecule compound library to identify novel chemical hit matter
  • Apply compound capture mass spectroscopy to identify the molecular targets of hit molecules

 

With this project, we aim to achieve the following results:

 

  • A validated 3D phenotypic assay for evaluating effects of antiviral drugs and/or RNAi/CRISPR-mediated genome modulations on host factors influencing viral infections
  • A hit list and associated compound structures of up to ~1% of the total number of compounds tested
  • Identification of putative novel targets for antiviral therapy

 

This project also includes three secondments, which are as follows:

 

  • A two-week secondment at the Hubrecht Institute (location: Utrecht, The Netherlands) to learn basic gut organoid culturing skills.
  • A three-month secondment with Amsterdam UMC (location: Amsterdam, the Netherlands) focused on learning application of organoid technology for viral infection research.
  • A three-month secondment with KU Leuven (location: Leuven, Belgium) to introduce HTS screening for antiviral drug testing.

 

You will be guided during your research project by Jeroen de Groot (Senior Director Biology) and Marijn Vlaming (Director Biology).

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, life sciences, pharmaceutical sciences or equivalent.  Hands on experience with cell culturing/in vitro biology obtained during undergraduate studies is required. Interest and experience with infectious disease or immunology research, complex in vitro models, such as stem cells and 3D/organoid culturing, and/or experience with high content imaging and data analysis are an advantage. The candidate is required to be proficient in the English language (verbal and written), a real team player, have a pro-active and independent attitude, have problem-solving and organizational skills, be accurate and have attention to detail. Furthermore, the candidate should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a research position for 40 hours per week within a motivated and innovative consortium. The salary will be in accordance with Charles River rules of employment and will include a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 14: Ethics & organoids

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

 

Project title: Ethical aspects of organoids (ESR 14)

 

Host institution: Centre for biomedical ethics and law, Faculty of Medicine, University of Leuven (Belgium)

 

About the host institution

 

In 2016 and 2017 the University of Leuven (KUL) was listed by Thomson Reuters in the annual list of Europe’s most innovative universities. The Centre for Biomedical Ethics and Law (KUL-CBMER) is part of the University of Leuven (KUL). The  KUL-CBMER is a renowned research centre in Europe with expertise in ethics, law, philosophy and theology and close links with various medical and care disciplines.

 

 

Project description

 

This project focuses on the ethical and social challenges of organoids, with due attention to implications for policy.

 

During this project, you will be focussing 1) on the ethical status of organoids (in which way are organoids related to the human donor? Can we use all kinds of stem cells for making organoids?), and 2) on the implications of the use of organoids regarding the replacement and reduction of animals in experimental medical research.  This will be done by investigating the existing literature and setting up empirical tools to explore the attitudes and opinions of different stakeholders (such as donors, researchers, biobank managers, policy makers, experts  involved in the use of animals for research, etc.) on the development of adaptive structures.  A cooperative analysis on ethical policies will be conducted in different European countries.

 

With this project, we aim to achieve the following results:

 

  • Establishment of the state of the art of the ethical aspects of the use of organoids.
  • Establishment of the views of key stakeholders on the use of organoids.
  • Development of an ethical framework for the use of organoids in medical research.

 

This project also includes two secondments, which are as follows:

 

  • A five-months secondment with the National (Dutch) Institute for Public Health and the Environment (location: the Netherlands) focused on the policy implications of the use of organoids
  • A two-month secondment with the Dutch Society for the Replacement of Animal Testing (location: the Netherlands) to develop tools to communicate with various stakeholders and the general public.

 

You will be guided during your research project by Kris Dierickx, professor of biomedical ethics at KU Leuven.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of (bio)ethics, philosophy, life sciences, biology, social or political sciences with interest in the ethics and governance of new biomedical technology. Experience with qualitative research methods is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of his/her research career. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

The selected candidates will be enrolled in a KU Leuven PhD program on a full-time basis for 36 months, and will receive a competitive salary in accordance with the EC MSCA regulations for early stage researchers.  Efforts will be made to acquire additional funding for the 4th PhD year.

 

In addition to their individual scientific projects, the selected researchers will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences within a motivated and innovative consortium. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.

ESR 15: Entrepreneurship & organoids

About Organovir

 

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America.

 

The application deadline for all research projects is the 1st of April , 2019.

 

 

 

Project title: Determinants of investments in biomedical entrepreneurship (ESR 15)

 

Host institution: Amsterdam Business School (ABS), University of Amsterdam, the Netherlands

 

 

About the host institution

 

ABS is one of Europe’s major comprehensive universities, truly international in research, curriculum, staff and students. It is promoting excellence and leadership in all business areas and has its research fully integrated into the study programs with small-scale interactive seminars, linking theory to practice, taught by renowned academics and practitioners. Th e Amsterdam Business School (ABS) is part of the University of Amsterdam’s Faculty of Economics and Business. ABS Master in Business Administration was #1 ranked in 2016 and the school is internationally recognized triple-crown accredited. It has around 4,000 full-time students and 140 FTE academic staff. One of the school’s core focus areas is the application of Data Science in all areas of business studies: Marketing, Finance, Operations Management, HR, Accounting and Strategy. To stimulate Big Data & Business Analytics, the school actively participates in Amsterdam Data Science, an all department initiative of the University of Amsterdam (UvA), the VU University Amsterdam VU), the Amsterdam University of Applied Sciences (HvA) and the Center for Mathematics & Computer Science (CWI). Within Amsterdam Data Science, a large number of research projects on Data Science take place, both with a theoretical focus and with an applied / industrial focus.

 

 

Project description

 

The main aim of this project is to study early investment in biotech entrepreneurial ventures, focusing on the signals of quality the entrepreneur and the venture can send and especially on the effects of how the entrepreneur or venture are categorized, in terms of industry, technology, goal of the product etc. – or categorize themselves.

 

The research will combine insights from management science, especially entrepreneurship and innovation, with those from categorisation theory, both in management science and in sociology, and apply a broad range of quantitative techniques, from network analysis to machine learning (esp. to analyse texts and images).

 

This project also includes a secondment, which is a ten-month visit at Charles River (location: Leiden, the Netherlands) focused on gathering empirical data on the decision making in new investments in organoid technology by commercial partners

 

You will be guided during your research project by Prof.dr. Nachoem Wijnberg and Dr. Balazs Szatmari.

 

 

Requirements

 

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of management science, econometrics, economics, sociology, computer science, or a related discipline The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment.  Find an overview of the requirements on our website.

 

 

What we offer

 

We offer a 3-year research position for 36 hours per week within a motivated and innovative consortium (with the possibility of extension). The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

 

 

Apply now for this research position.